CSP #575-B: Genomics of Posttraumatic Stress Disorder in Veterans - VA Cooperative Studies Program (CSP)
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VA Cooperative Studies Program (CSP)


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CSP #575-B: Genomics of Posttraumatic Stress Disorder in Veterans


Investigator Access

What's available

Research resources generated by this study are not available at this time. For more information about access in the future, contact Patricia.Crutchfield@va.gov.

Available documentation 


Dates data are available 


Access criteria


Study Characteristics


To identify genes that affect the risk of developing posttraumatic stress disorder (PTSD) and to help improve understanding and treatment of this condition

Era of Service



Inclusion criteria:

  • Combat-exposed male and female Veterans who participated in the Million Veteran Program (MVP), which includes active users of the Veterans Health Administration (VHA)
  • Cases: Veterans diagnosed with PTSD
  • Controls: Veterans with no diagnosis of PTSD

Exclusion criteria:

  • Veterans with schizophrenia or bipolar disorder

Study Design 

Case-control (genomic)

Time Period 

2013 - 2018




20,000 (estimated)

Response Rate

600 Veterans invited to participate in a telephone interview; response rate pending

Recruitment Method    

Potential PTSD cases in the MVP database are initially identified based on self-report of a PTSD diagnosis on a previously completed questionnaire collected in MVP, or evidence of a PTSD diagnosis in the VA electronic health record; a validated algorithm narrows the pool to confirmed PTSD cases and controls.


$50 for telephone (validation) interview

Data Collected

  • Clinical data
  • Demographics
  • Diagnosis of PTSD & depression

Data Collection Methods

  • MVP database
  • VA electronic health records
  • Telephone interviews

Funding Sources 

VA Cooperative Studies Program (CSP)


Patricia.Crutchfield@va.gov   /   203-932-5711, x5884

Selected Publications 

Radhakrishnan K, Aslan M, Harrington KM, Pietrzak RH, Huang G, Muralidhar S, Cho K, Quaden R, Gagnon D, Pyarajan S, Sun N, Zhao H, Gaziano M, Concato J, Stein MB, Gelernter J. Genomics of posttraumatic stress disorder in veterans: Methods and rationale for Veterans Affairs Cooperative Studies #575B. Int J Methods Psychiatr Res. 2019 Mar;28(1):e1767

More Information

Study website 
Study ClinicalTrials.gov site
ClinicalTrials.gov Identifier: NCT02256644