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VA Cooperative Studies Program (CSP)

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CSP #575-B: Genomics of Posttraumatic Stress Disorder in Veterans


Investigator Access

What's Available


Check with the study contact and publications for information on a public dataset, data archive, data enclave, or website where data might be available


Available Documentation 

Dates data are Available 

Access Criteria

Study Characteristics


To identify genes that affect the risk of developing posttraumatic stress disorder (PTSD), and to help improve understanding and treatment of this condition

Era of Service



Inclusion criteria:

  • Combat-exposed male and female Veterans who participated in the Million Veteran Program (MVP), which includes active users of the Veterans Health Administration (VHA)
  • Cases: Veterans diagnosed with PTSD
  • Controls: Veterans with no diagnosis of PTSD

Exclusion criteria:

  • Veterans with schizophrenia or bipolar disorder

Study Design 

Case-control (genomic)

Time Period 

2013 - 2018




20,000 estimated participants

Response Rate

600 Veterans invited to participate in a telephone interview; response rate unconfirmed

Recruitment Method    

Potential PTSD cases in the MVP database are initially identified based on self-report of a PTSD diagnosis on a previously completed questionnaire collected in MVP, or evidence of a PTSD diagnosis in the VA electronic health record; a validated algorithm narrows the pool to confirmed PTSD cases and controls.


$50 for telephone (validation) interview

Data Collected

  • Clinical data
  • Demographics
  • Diagnosis of PTSD & depression

Data Collection Methods

  • MVP database
  • VA electronic health records
  • Telephone interviews

Funding Source

VA Cooperative Studies Program (CSP)


Study Co-Investigator: Murray B. Stein, MD, MPH
Study Co-Investigator: Joel Gelernter, MD


Study Chair: Patricia Crutchfield,

Selected Publications 

Radhakrishnan K, Aslan M, Harrington KM, Pietrzak RH, Huang G, Muralidhar S, Cho K, Quaden R, Gagnon D, Pyarajan S, Sun N, Zhao H, Gaziano M, Concato J, Stein MB, Gelernter J. Genomics of posttraumatic stress disorder in veterans: Methods and rationale for Veterans Affairs Cooperative Studies #575B. Int J Methods Psychiatr Res. 2019 Mar;28(1):e1767.

Levey DF, Gelernter J, Polimanti R, Zhou H, Cheng Z, Aslan M, Quaden R, Concato J, Radhakrishnan K, Bryois J, Sullivan PF; Million Veteran Program, Stein MB. Reproducible Genetic Risk Loci for Anxiety: Results From ∼200,000 Participants in the Million Veteran Program. Am J Psychiatry. 2020 Jan 7:appiajp201919030256.

More Information

  • Study site
  • Identifier: NCT02256644
  • Dimensions for VA summary (Requires an account to access outside the VA network. Dimensions for VA is a database that connects publications, grants, patents, clinical trials, and policy documents)