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VA Cooperative Studies Program (CSP)

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CSP #499-A: ACTIVE Health

Full title:
Relatively Healthy Male Veterans Observed Over Time to See What Types of Diseases Develop (ACTIVE Health) 

Investigator Access

What's Available

Check with the study contact and publications.


Available Documentation

Dates Data are Available
Access Criteria

Study Characteristics


To gather and follow a racially-mixed group of relatively healthy male Veterans to observe what types of diseases they develop and to determine if racial differences in lifestyle, blood test results, or genes are related to the types of diseases that are found.

Era of Service



Relatively healthy male Veterans aged 50 years and older, expected to live more than 5 years

Study Design 

Prospective cohort

Time Period 

2002 - 2021; Each participant to be followed for at least five years





Response Rate


Recruitment Method    

Veterans recruited from VA medical centers across the country in parallel with recruitment for Selenium and Vitamin E Cancer Prevention Trial (SELECT).



Data Collected

  • Demographics
  • Medical history
  • Information on lifestyle such as physical activities, smoking, and drinking
  • Information on diet, quality of life, and experience of medical events 
  • Specific diagnoses including prostate cancer, lung cancer, colon cancer, other cancers, stroke, myocardial infarction, hypertension, diabetes mellitus, kidney disease, chronic prostatitis, and benign prostatic hypertrophy

Data Collection Methods

  • Questionnaire
  • VA clinical and administrative databases
  • Self-reported experience of medical events/diagnoses
  • Confirmation of self-reported diagnosis made by an examination of discharge summaries, medical records, and available diagnostic and laboratory information by an end-points committee

Funding Source

VA Cooperative Studies Program (CSP)


J. Michael Gaziano, MD, MPH


Selected Publications 


More Information

  • Study site
  • Identifier: NCT00076141
  • Dimensions for VA summary (Requires an account to access outside the VA network. Dimensions for VA is a database that connects publications, grants, patents, clinical trials, and policy documents)