CSP #499-A: ACTIVE Health - VA Cooperative Studies Program (CSP)
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VA Cooperative Studies Program (CSP)


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CSP #499-A: ACTIVE Health

 Full title:
Relatively Healthy Male Veterans Observed Over Time to See What Types of Diseases Develop (ACTIVE Health) 

Data Sharing Statement

What's available

Check with the study contact and publications for information on where data may be available

Study Characteristics


To gather and follow a racially-mixed group of relatively healthy male Veterans to observe what types of diseases they develop and to determine if racial differences in lifestyle, blood test results, or genes are related to the types of diseases that are found.

Era of Service



Relatively healthy male Veterans aged 50 years and older, expected to live more than 5 years

Study Design 

Prospective cohort

Time Period 

2002 - 2021; Each participant to be followed for at least five years





Response Rate


Recruitment Method    

Veterans recruited from VA medical centers across the country in parallel with recruitment for Selenium and Vitamin E Cancer Prevention Trial (SELECT).



Data Collected

  • Demographics
  • Medical history
  • Information on lifestyle such as physical activities, smoking, and drinking
  • Information on diet, quality of life, and experience of medical events 
  • Specific diagnoses including prostate cancer, lung cancer, colon cancer, other cancers, stroke, myocardial infarction, hypertension, diabetes mellitus, kidney disease, chronic prostatitis, and benign prostatic hypertrophy

Data Collection Methods

  • Questionnaire
  • VA clinical and administrative databases
  • Self-reported experience of medical events/diagnoses
  • Confirmation of self-reported diagnosis made by an examination of discharge summaries, medical records, and available diagnostic and laboratory information by an end-points committee

Funding Sources 

VA Cooperative Studies Program (CSP)



Selected Publications 


More Information

Study ClinicalTrials.gov site 
ClinicalTrials.gov Identifier: NCT00076141