Attention A T users. To access the menus on this page please perform the following steps. 1. Please switch auto forms mode to off. 2. Hit enter to expand a main menu option (Health, Benefits, etc). 3. To enter and activate the submenu links, hit the down arrow. You will now be able to tab or arrow up or down through the submenu options to access/activate the submenu links.

VA Cooperative Studies Program (CSP)

Quick Links
Veterans Crisis Line Badge
My healthevet badge

CSP #334: Psychophysiological Assessment of PTSD


Investigator Access

What's Available

Check with the study contact and publications for information on a public dataset, data archive, data enclave, or website where data might be available.

Available Documentation

Dates Data are Available

Access Criteria

Study Characteristics


  • To evaluate the extent to which psychophysiological measures can predict the presence of post-traumatic stress disorder (PTSD) as determined by the Structured Clinical Interview for DSM-III-R (SCID)
  • To develop psychological and physiological tests that can provide the means to accurately diagnose PTSD and evaluate the progress of patients who are being treated

Era of Service



Male Veterans who served in the Vietnam theater of operations between August 1964 and May 1975 and were using VA services

Study Design


Time Period

January 1990 – March 1992




1,328 participants

Response Rate


Recruitment Method

Participants were recruited from VA Medical Center inpatient and outpatient programs in psychiatry, substance abuse, and PTSD.



Data Collected

Data were collected on:

  • Sociodemographic characteristics
  • Psychosocial history
  • Mental health indicators (e.g., combat-related guilt, exposure to trauma)
  • Psychological diagnoses (PTSD, major depression, bipolar disorder, schizophrenia, substance abuse, panic disorder, social phobia, obsessive-compulsive disorder, somatoform disorder, dissociative disorder, antisocial disorder, borderline personality disorders)
  • Psychophysiological response indicators (heart rate, skin conductance, forehead electromyogram, and systolic and diastolic blood pressure)

Data Collection Methods

Data were collected via:

  • Structured questionnaires
  • SCID and SCID-II diagnostic interview modules administered by VA clinicians
  • Psychophysiological assessment conducted in a laboratory

Funding Source

VA Cooperative Studies Program (CSP)


Lawrence C. Kolb, MD

Terence M. Keane, PhD

Danny G. Kaloupek, PhD


Terence M. Keane, PhD,

Selected Publications

Keane TM, Kolb LC, Kaloupek DG, Orr SP, Blanchard EB, Thomas RG, Hsieh FY, Lavori PW. Utility of psychophysiological measurement in the diagnosis of posttraumatic stress disorder: results from a Department of Veterans Affairs Cooperative Study. J Consult Clin Psychol. 1998 Dec;66(6):914-23.

Taft CT, Kaloupek DG, Schumm JA, Marshall AD, Panuzio J, King DW, Keane TM. Posttraumatic stress disorder symptoms, physiological reactivity, alcohol problems, and aggression among military veterans. J Abnorm Psychol. 2007 Aug;116(3):498-507.

Miller MW, Fogler JM, Wolf EJ, Kaloupek DG, Keane TM. The internalizing and externalizing structure of psychiatric comorbidity in combat veterans. J Trauma Stress. 2008 Feb;21(1):58-65.

Lenhardt JM, Howard JM, Taft CT, Kaloupek DG, Keane TM. Examining aggression in male Vietnam veterans who receive VA services: the role of traumatic events and combat exposure. J Trauma Stress. 2012 Aug;25(4):461-4.

More Information

Study summary in PTSD Research Quarterly, Vol 9, No 1, Winter 19981 

1 This link takes you to a non-U.S. government website. VA isn't responsible for the content or privacy policies on that site and doesn't endorse the content or its sponsor.