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VA Cooperative Studies Program (CSP)

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CSP #2006: Genomics of Gulf War Illness in Veterans


Investigator Access

What's Available

Check with the study contact and publications for information on a public dataset, data archive, data enclave, or website where data might be available.

Available Documentation

Dates Data are Available

Access Criteria

Study Characteristics


To evaluate potential genetic risk factors for Gulf War Illness (GWI) by conducting a genome-wide association study

Era of Service

Gulf War


1990-1991 Gulf War Era Veterans who participated in the Million Veteran Program (MVP), which includes active users of the Veterans Health Administration (VHA)

Study Design 

  • Case-control design nested within MVP, with genes (genotype) as the exposure variable and GWI (yes/no) as the outcome variable
  • Source population will include both deployed and non-deployed 1990-1991 Gulf War Era Veterans among MVP enrollees

Time Period 

2018 - 2019




7,500 case participants; 7,500 control participants (estimated)

Response Rate


Recruitment Method    

Among MVP participants, Veterans who meet the CSP #2006 eligibility criteria are sent an invitation packet consisting of an invitation letter, fact sheet and survey; interested Veterans are asked to mail the completed survey back for inclusion in the study, and genetic data and other medical information is collected per MVP.



Data Collected

  • Demographics
  • Survey data related to Gulf War Illness (e.g., Gulf War experience and subsequent health conditions)
  • Genetic data from MVP

Data Collection Methods

  • Genetic data of eligible participants will be collected under the MVP protocol
  • Survey data will be obtained from administering a follow-up mailed survey to those Veterans

Funding Sources 

VA Cooperative Studies Program (CSP)


Drew Helmer, MD, MPH


Alysia Maffucci, 

Selected Publications 


More Information

 Study website