CSP #2006: Genomics of Gulf War Illness in Veterans - VA Cooperative Studies Program (CSP)
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VA Cooperative Studies Program (CSP)


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CSP #2006: Genomics of Gulf War Illness in Veterans


Data Sharing Statement

What's available

Research resources generated by this study are not available at this time. For more information about access in the future, contact Alysia.Maffucci@va.gov.

Study Characteristics


To evaluate potential genetic risk factors for Gulf War Illness (GWI) by conducting a genome-wide association study

Era of Service

Gulf War Era


1990-1991 Gulf War Era Veterans who participated in the Million Veteran Program (MVP), which includes active users of the Veterans Health Administration (VHA)

Study Design 

  • Case-control design nested within MVP, with genes (genotype) as the exposure variable and GWI (yes/no) as the outcome variable
  • Source population will include both deployed and non-deployed 1990-1991 Gulf War Era Veterans among MVP enrollees

Time Period 

2018 - 2019




7,500 case participants; 7,500 controls (estimated)

Response Rate

Not available; study in start-up/initiation phase

Recruitment Method    

Among MVP participants, Veterans who meet the CSP #2006 eligibility criteria are sent an invitation packet consisting of an invitation letter, fact sheet and survey; interested Veterans are asked to mail the completed survey back for inclusion in the study, and genetic data and other medical information is collected per MVP.



Data Collected

  • Demographics
  • Survey data related to Gulf War Illness (e.g., Gulf War experience and subsequent health conditions)
  • Genetic data from MVP

Data Collection Methods

  • Genetic data of eligible participants will be collected under the MVP protocol
  • Survey data will be obtained from administering a follow-up mailed survey to those Veterans

Funding Sources 

VA Cooperative Studies Program (CSP)


Alysia.Maffucci@va.gov   /   203-932-5711, x5697

Selected Publications 


More Information

Study ClinicalTrials.gov site (pending)